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ADWFC-12P Reciprocating Cylinder Method Dissolution Sampling Collection System

 ADWFC-12P Reciprocating Cylinder Method Dissolution Sampling Collection System

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Reciprocating cartridge dissolution meter for in vitro dissolution pH profile analysis by simple programming to simulate biologically relevant temperatures, stirring rates and retention times in the gastrointestinal tract and tissues. It is widely used for dissolution of various types of slow and controlled release formulations. Such as slow-release micro-pills, slow-release formulations with HPMC skeleton. It can also be used for release rate testing of floating agents, microspheres and chewing agents. One machine with two modes (USP3 method, USP7 method switching), one machine with two tests (two rows and two samples), one machine with multiple uses. It can run automatically for a long time according to the program when unattended, and the connection of sampler can automatically complete the sampling, which makes the efficiency and experience of human-machine interaction greatly improved.The design of RCWF-1 is in line with the 2020 edition of the Chinese Pharmacopoeia, in line with the current USP3 method and USP7 method, and in line with the EP's performance index requirements for the reciprocating cartridge method.


 


Automated programmed operation:

The RCWF-1 can automatically transfer samples to customized test positions, has a deflectorized anti-volatility lid that opens and closes automatically, and can be programmed to run for long periods of time when unattended.

Flexible Programming

The RCWF-1 can be freely programmed with direct control of wetting time, draining time, reciprocation rate, reciprocation time, reciprocation stroke, sampling frequency, customized test positions, and movement between rows of dissolution cups. Single-row or double-row tests can be selected independently. The USP3 method and USP7 method can be freely switched. The open program facilitates drug development.

Dual Row Sample Position

The RCWF-1 is equipped with a double-row sample position, which allows simultaneous testing of up to 14 cups of samples, facilitating comparative testing of original and generic samples under the same conditions.

Flexible Sampling Points

The RCWF-1 is equipped with an elevation range that allows for full height positioning of the sampling needle.

 


Reciprocating Cylinder Dissolution Analyzer Performance Indicators:


Water bath temperature: room temperature ~ 45 ℃

Temperature resolution: 0.1℃

Temperature control error: ≤±0.2℃.

Reciprocating stroke: CHP7/USP3:10±0.1cm

                  USP7:2cm

Reciprocation Frequency: 1~50 times/minute Error: ±5%

Sample position: 300ml specification dissolution cup 7 cups 8 rows (single row) or 14 cups 4 rows (double row), single, double row adjustable

Ambient temperature: 5 ~ 40 ℃

Relative humidity: ≤80%


Working noise: ≤60dB

Running time: adjustable

Submergence time: adjustable

Drain time: adjustable

Heater: 1500W

Power supply: 220V, 50Hz, 10A

Safety performance: in line with national industry standards, with self-test and automatic protection function

 


RZQ-12P sampler is a new type of sampler newly developed by Tianda Tianfa, which is used in the dissolution instrument and reciprocating cylinder dissolution instrument produced by Tianda Tianfa to connect to form a dissolution sampling system with fast sampling speed and flexible programming to meet the requirements of pharmacopoeia of various countries on dissolution sampling and filtration time. To meet the data integrity requirements, it can be connected to Tenda Tianfa ADK-1 data integrity system management platform and LIMS system.


Main performance characteristics:


Equipped with pre-filtration and terminal filtration, the filter can be fully recycled and rinsed, easy to replace.

Sampling using sample bottles with new sealing cap (1.5mL, 10mL), or 10mL test tubes

Sampling needles with needling and ejection mechanism and built-in PTFE tubing

Automatic syringe flip operation (simulates manual operation, venting upward or downward as needed)

High precision (repeatability RSD <0.5%)

Fast speed (pump speed <25mL/min, complete sampling and filtration process within 30s in most cases)

Can be directly diluted (up to 20 times)

Flexible configuration (can be software set to 12-channel work, 8-channel work)

Flexible programming (through the template way, can be later to do a variety of action programming, widely adapted to various situations, cloud server download)

 


Main technical indicators:


Sampling times: unlimited (16 times per batch), manual replacement of the sample disk

Sample holder: 12X16 holes

Sampling volume: 0.1-10mL, 20mL (double row) 30mL (three row)

Sampling interval: ≥2min      

Sampling consistency: RSD ≤ 1% between channels

Sampling repeatability: RSD ≤ 1%

Communication interface: RS232, RS485, network

Online filter: 0.45μm, 0.8μm luer connector filter

Liquid flow rate: programmable, ≤25mL/min

Method storage: a variety of flexible programming to adapt to various situations.


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